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Abstract #0402

Sodium MRI at 7 Tesla as quantitative biomarker to assess tumor heterogeneity and histologic subtypes in glioma patients

Daniel Paech1, Sebastian Regnery2, Nicolas Behl3, Tanja Platt3, Nina Weinfurtner1, Mark Edward Ladd3, J├╝rgen Debus2, Sebastian Adeberg2, and Heinz-Peter Schlemmer1
1Radiology, German Cancer Research Center, Heidelberg, Germany, 2Radiooncology, University Hospital Heidelberg, Heidelberg, Germany, 3Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

23Na MRI provides information on physiologic and pathophysiologically altered tissue sodium concentrations in vivo. In this prospective trial, we investigated the potential of 23Na MRI at 7.0 Tesla to predict the tumor grade and genetic subtypes (such as isocitrate dehydrogenase (IDH) mutation and O6-methylguanine DNA methyltransferase (MGMT) promotor methylation) in a study cohort of 28 glioma patients. We show that that the quantitative 23Na signal correlates with tissue-specific tumor subcompartments and that the contrast may allow non-invasive assessment of the tumor grade and IDH mutation.

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