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Abstract #0403

Differentiation of IDH Mutant from IDH wild-type High-grade Gliomas using Combined Analysis of Diffusion and Perfusion MRI

Santosh Kumar Yadav1, Sumei Wang2, Shadi Asadollahi2, MacLean Nasrallah3, Steven Brem4, Mohammad Haris1, Suyash Mohan2, and Sanjeev Chawla2
1Research, Sidra Medicine, Doha, Qatar, 2Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 3Department of Pathology and Lab Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 4Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States

Accurate identification of isocitrate dehydrogenase (IDH) mutant high-grade glioma is clinically important. We investigated the combined utility of diffusion (DTI) and perfusion (DSC-PWI) MR imaging in distinguishing IDH mutant from IDH wild-type high-grade gliomas. Treatment naïve patients (n=30) with IDH-mutant (n=14) and IDH-wild-type (n=16) high-grade gliomas were recruited. A classification model comprising of mean diffusivity, coefficient of planar anisotropy and maximum relative cerebral blood volume differentiated two genotypes of gliomas with an accuracy of 85%, a sensitivity of 87.2%, and a specificity of 81.5%. Combined analysis of DTI and DSC-PWI may be helpful in distinguishing IDH profiles of high-grade gliomas.

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