Abstract #0404

Glioma 2HG threshold setting based on normal appearing white matter increases the diagnostic value of 3D MEGA-LASER for IDH mutation detection

Marzena Wylezinska-Arridge^1,2, Enrico De Vita^2,3, Laura Mancini^1,2, Ovidiu Andronesi⁴, Wolfgang Bogner⁵, Bernhard Strasser⁴, Tarek Yousry^1,2, John Thornton^1,2, and Sotirios Bisdas^1,2

¹Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ²Institute of Neurology, University College London, London, United Kingdom, ³Department of Biomedical Engineering. School of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁵High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria

It has been established that 2-hydroxyglutarate (2GH) MRS is important for non-invasive diagnosis of isocitrate dehydrogenase (IDH) status that holds prognostic value for the patient and is important for treatment planning. The purpose of this work was to investigate whether the threshold determination for identification of IDH mutation could be improved by using ‘control’ spectra from normal-appearing white matter, NAWM , in multi-voxel 3D MEGA-LASER acquisitions. The proposed approaches to threshold determination for 2HG detection in the tumour voxels provided increased sensitivity and specificity as compared with the cut-off thresholds based on CRLB% relative error.

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