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Abstract #0408

Stereotactic tissue sampling and T1-, T2-relaxometry compared with ADC for tissue cell density quantification in gliomas imaging

Manabu Kinoshita1,2, Masato Uchikoshi3, Souichiro Tateishi2, Shohei Miyazaki2, Mio Sakai2, Tomohiko Ozaki2, Katsunori Aasai2, Yuya Fujita2, Takahiro Matsuhashi2, Yonehiro Kanemura4, Eku Shimosegawa1, Jun Hatazawa1, Shin-ichi Nakatsuka2, Haruhiko Kishima1, and Katsuyuki Nakanishi2
1Osaka University Graduate School of Medicine, Suita, Japan, 2Osaka International Cancer Institute, Osaka, Japan, 3Canon Medical Systems Corporation, Tochigi, Japan, 4National Hospital Organization Osaka National Hospital, Osaka, Japan

The authors attempted to elucidate the correlation of tumor cell density within the brain in glioma patients and T1-, T2-relaxometry and ADC. First, an exploratory study compared T1-, T2-relaxometry, and ADC with 11C-methionine PET followed by a validation study using intraoperative stereo-tactically obtained tissues. A range of T1 values indicative of high cell density was identified, which finding was confirmed by stereotactic tissue sampling. For T2 values and ADC, however, no statistically significant correlation was confirmed regarding tumor cell density. The proposed technique was further able to create predictive tumor cell density map by T1 supplemented by T2 values.

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