Abstract #0408

Stereotactic tissue sampling and T1-, T2-relaxometry compared with ADC for tissue cell density quantification in gliomas imaging

Manabu Kinoshita^1,2, Masato Uchikoshi³, Souichiro Tateishi², Shohei Miyazaki², Mio Sakai², Tomohiko Ozaki², Katsunori Aasai², Yuya Fujita², Takahiro Matsuhashi², Yonehiro Kanemura⁴, Eku Shimosegawa¹, Jun Hatazawa¹, Shin-ichi Nakatsuka², Haruhiko Kishima¹, and Katsuyuki Nakanishi²

¹Osaka University Graduate School of Medicine, Suita, Japan, ²Osaka International Cancer Institute, Osaka, Japan, ³Canon Medical Systems Corporation, Tochigi, Japan, ⁴National Hospital Organization Osaka National Hospital, Osaka, Japan

The authors attempted to elucidate the correlation of tumor cell density within the brain in glioma patients and T1-, T2-relaxometry and ADC. First, an exploratory study compared T1-, T2-relaxometry, and ADC with 11C-methionine PET followed by a validation study using intraoperative stereo-tactically obtained tissues. A range of T1 values indicative of high cell density was identified, which finding was confirmed by stereotactic tissue sampling. For T2 values and ADC, however, no statistically significant correlation was confirmed regarding tumor cell density. The proposed technique was further able to create predictive tumor cell density map by T1 supplemented by T2 values.

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