Brain tumor adherence has been long recognized to impact surgical resection difficulty. Recently-developed slip interface imaging (SII) can preoperatively predict tumor-brain adhesion. In previous studies, subjectively-determined SII assessment of tumor adhesion has been shown to agree well with intraoperative findings. The purpose of this work was to develop an objective quantitative method for analyzing SII data for adherence, thereby minimizing inter- and intraobserver variability. We developed a radiomics-based metric (termed “adhesion degree”) based on SII to quantify the degree of tumor adhesion. In 46 meningiomas, the adhesion degree showed excellent accuracy in predicting completely adherent tumors (AUROC=0.96) from non-adherent tumors.