Preoperative information of tumor consistency is important in patients with pituitary adenoma. Our aim was to evaluate the possible role of high-temporal and spatial resolution dynamic contrast enhanced MR imaging (DCE-MRI) and quantitative pharmacokinetic analysis in differentiation of a hard adenoma from soft adenoma. The hard adenoma showed significantly higher extravascular extracellular space per unit volume of tissue (ve) than soft adenoma and the ve was significantly correlated to collagen IV content of pituitary adenomas. This quantitative pharmacokinetic parameter ve may be useful for differentiation of the hard adenoma from soft adenoma.
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