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Abstract #0430

Benchmarking acinar airway measurements from inhaled nanoparticles with hyperpolarized 129Xe diffusion-weighted MRI

Ho-Fung Chan1, Madeleine Petersson Sjögren2, Paul J.C. Hughes1, Oliver I Rodgers1, Guilhem J Collier1, Graham Norquay1, Lars E Olsson3, Per Wollmer3, Jakob Löndahl2, and Jim M Wild1
1Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2Division of Ergonomics and Aerosol Technology, Lund University, Lund, Sweden, 3Department of Translational Medicine, Lund University, Malmö, Sweden

Airspace Dimension Assessment with inhaled nanoparticles (AiDA) and hyperpolarized 129Xe diffusion-weighted (DW)-MRI was performed in twenty-three healthy volunteers to benchmark measurements from AiDA against those from 129Xe DW-MRI. Significant correlations were observed between AiDA derived root mean square distal airspace radius, and 129Xe apparent diffusion coefficient and diffusion model derived acinar airway dimensions. Furthermore, the AiDA recovery at zero-second breath-hold significantly correlated with 129Xe alpha index from the stretched exponential model, a marker of acinar airspace heterogeneity. This benchmarking study demonstrates the potential of AiDA as an alternative method for the clinical evaluation of acinar airway microstructure changes.

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