Abstract #0431

Quantitative dose-dependent changes in regional lung function after radiation therapy detected using xenon-129 gas exchange MRI

Leith Rankine^1,2, Ziyi Wang¹, Elianna Bier¹, Christopher Kelsey³, Shiva Das², Lawrence Marks², and Bastiaan Driehuys¹

¹Center for In Vivo Microscopy, Duke University, Durham, NC, United States, ²Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, United States, ³Department of Radiation Oncology, Duke University Medical Center, Durham, NC, United States

Radiation therapy (RT) is widely used to treat lung cancer, but damage to surrounding healthy tissues can lead to compromised lung function. In this study, patients undergoing RT were imaged pre- and post-treatment using hyperpolarized ¹²⁹Xe gas exchange MRI to assess for RT-induced changes in regional lung function. At 3-months post-treatment, a dose-response was evident in ventilation and gas exchange. Lung regions receiving ≥20Gy exhibited significantly increased barrier uptake and decreased RBC transfer. This may help radiation oncologists further understand the dose-dependence of RT-induced lung injury, and design dose distributions with fewer treatment toxicities.

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