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Abstract #0432

Imaging Regional Capillary Cardio-Pulmonary Blood Flow Dynamics using Hyperpolarized 129Xe MRI and Keyhole Reconstruction

Peter James Niedbalski1, Elianna A Bier2,3, Ziyi Wang2,3, Matthew M Willmering1, Bastiaan Driehuys2,3,4, and Zackary I Cleveland1,5
1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Department of Biomedical Engineering, Duke University, Durham, NC, United States, 3Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, 4Department of Radiology, Duke University Medical Center, Durham, NC, United States, 5Department of Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH, United States

Hyperpolarized 129Xe MRI offers the ability to analyze pulmonary gas transfer by imaging 129Xe dissolved in red blood cells (RBCs) separately from 129Xe in other tissues. A notable feature of the dissolved 129Xe signal is the presence of small cardiogenic oscillations in the 129Xe RBC signal, which have been used to characterized global abnormalities in pulmonary microvascular hemodynamics. Here, we demonstrate that these cardiogenic oscillations can be mapped 3-dimensionally to image capillary bed hemodynamics. Our approach uses keyhole reconstruction of standard 129Xe gas exchange MR acquisitions. Metrics obtained from these maps distinguished healthy from disease cohorts and predicted disease progression.

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