Abstract #0432

Imaging Regional Capillary Cardio-Pulmonary Blood Flow Dynamics using Hyperpolarized 129Xe MRI and Keyhole Reconstruction

Peter James Niedbalski¹, Elianna A Bier^2,3, Ziyi Wang^2,3, Matthew M Willmering¹, Bastiaan Driehuys^2,3,4, and Zackary I Cleveland^1,5

¹Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Department of Biomedical Engineering, Duke University, Durham, NC, United States, ³Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, ⁴Department of Radiology, Duke University Medical Center, Durham, NC, United States, ⁵Department of Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH, United States

Hyperpolarized ¹²⁹Xe MRI offers the ability to analyze pulmonary gas transfer by imaging ¹²⁹Xe dissolved in red blood cells (RBCs) separately from ¹²⁹Xe in other tissues. A notable feature of the dissolved ¹²⁹Xe signal is the presence of small cardiogenic oscillations in the ¹²⁹Xe RBC signal, which have been used to characterized global abnormalities in pulmonary microvascular hemodynamics. Here, we demonstrate that these cardiogenic oscillations can be mapped 3-dimensionally to image capillary bed hemodynamics. Our approach uses keyhole reconstruction of standard ¹²⁹Xe gas exchange MR acquisitions. Metrics obtained from these maps distinguished healthy from disease cohorts and predicted disease progression.

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