Abstract #0440

19F-MRI of inhaled perfluoropropane for assessment of pulmonary ventilation: a multi-centre reproducibility study in healthy volunteers

Mary Neal^1,2, Benjamin Pippard^1,2, Adam Maunder³, Rod Lawson⁴, Holly F. Fisher⁵, John N. S. Matthews⁵, Kieren Hollingsworth^1,2, A. John Simpson², Jim M. Wild³, and Pete Thelwall^1,2

¹Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, ²Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, ³POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom, ⁴Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, ⁵Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom

¹⁹F-MRI of inhaled perfluoropropane can be used to assess regional pulmonary ventilation. We conducted a prospective multi-centre reproducibility study in 40 healthy volunteers. Same-day static breath-hold ¹⁹F-MR images with 1 cm isotropic resolution were acquired on four occasions for each volunteer following inhalation of a perfluoropropane/oxygen gas mixture. Percentage ventilated lung volume (%VV) was calculated for all volunteers, reflecting the inhalation protocol, imaging protocol, and image registration and segmentation process applied. Volunteer %VV was determined to within ±1.7% (95% CI). Gas inhalations were well tolerated by all volunteers with no adverse events.

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