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Abstract #0440

19F-MRI of inhaled perfluoropropane for assessment of pulmonary ventilation: a multi-centre reproducibility study in healthy volunteers

Mary Neal1,2, Benjamin Pippard1,2, Adam Maunder3, Rod Lawson4, Holly F. Fisher5, John N. S. Matthews5, Kieren Hollingsworth1,2, A. John Simpson2, Jim M. Wild3, and Pete Thelwall1,2
1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, 3POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 4Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 5Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom

19F-MRI of inhaled perfluoropropane can be used to assess regional pulmonary ventilation. We conducted a prospective multi-centre reproducibility study in 40 healthy volunteers. Same-day static breath-hold 19F-MR images with 1 cm isotropic resolution were acquired on four occasions for each volunteer following inhalation of a perfluoropropane/oxygen gas mixture. Percentage ventilated lung volume (%VV) was calculated for all volunteers, reflecting the inhalation protocol, imaging protocol, and image registration and segmentation process applied. Volunteer %VV was determined to within ±1.7% (95% CI). Gas inhalations were well tolerated by all volunteers with no adverse events.

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