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Abstract #0442

Binning method for treatment response mapping with hyperpolarized gas lung MRI: application in subjects with asthma

Guilhem Jean Collier1, Alberto Biancardi1, Paul J Hughes1, Laurie Smith1, Grace T Mussel1, Helen Marshall1, Ho F Chan1, Graham Norquay1, and Jim M Wild1
1Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

This work applies a clustering method developed for image analysis of hyperpolarised gas lung ventilation MRI to a cohort of patients referred from a severe asthma clinic for investigation of breathlessness. Patients underwent spirometry tests and imaging at baseline and after inhalation of Salbutamol to assess reversibility. In a subset of patients, images pre and post bronchodilator were registered and a novel treatment response mapping method was applied. Results show significant correlations at baseline between imaging markers and FEV1% and between their percentage changes and the reversibility testing. The treatment response mapping method offers additional robust additional insights.

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