Meeting Banner
Abstract #0442

Binning method for treatment response mapping with hyperpolarized gas lung MRI: application in subjects with asthma

Guilhem Jean Collier1, Alberto Biancardi1, Paul J Hughes1, Laurie Smith1, Grace T Mussel1, Helen Marshall1, Ho F Chan1, Graham Norquay1, and Jim M Wild1
1Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

This work applies a clustering method developed for image analysis of hyperpolarised gas lung ventilation MRI to a cohort of patients referred from a severe asthma clinic for investigation of breathlessness. Patients underwent spirometry tests and imaging at baseline and after inhalation of Salbutamol to assess reversibility. In a subset of patients, images pre and post bronchodilator were registered and a novel treatment response mapping method was applied. Results show significant correlations at baseline between imaging markers and FEV1% and between their percentage changes and the reversibility testing. The treatment response mapping method offers additional robust additional insights.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here