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Abstract #0443

A Model for Interpreting Hyperpolarized 129Xe Gas Exchange MRI

Ziyi Wang1, Leith Rankine1, Aparna Swaminathan1, Elianna A Bier1, Matthew P Thorpe2, Robert Tighe1, Yuh Chin Huang1, Sudarshan Rajagopal1, and Bastiaan Driehuys1
1Duke University, Durham, NC, United States, 2Mayo Clinic, Rochester, MN, United States

Hyperpolarized 129Xe gas exchange (GX) MR imaging of pulmonary ventilation, barrier uptake and red blood cell (RBC) transfer has shown sensitivity to a wide range of pathology. However, the physiological interpretation of regional RBC transfer defects is not yet fully established and its connection to conventional measures has yet to be studied in a broad range of pathology. Here we evaluate the extent to which 129Xe RBC transfer reflects local perfusion, by testing its spatial correlation to 99mTc scintigraphy and propose a generalized model connecting 129Xe gas exchange metrics to the membrane and capillary blood volume components of DLCO.

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