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Abstract #0472

Mapping neuronal activity associated with finger tapping using direct measurement of 17O at 7 Tesla: proof-of-concept experiment

Tanja Platt1, Louise Ebersberger2,3, Vanessa L Franke1,4, Armin M Nagel1,5,6, Reiner Umathum1, Heinz-Peter Schlemmer2, Peter Bachert1,4, Mark E Ladd1,3,4, Andreas Korzowski1, Sebastian C Niesporek1, and Daniel Paech2
1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2Radiology, German Cancer Research Center, Heidelberg, Germany, 3Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, 4Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 5Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 6Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Dynamic 17O-MRI enables direct quantification of the cerebral metabolic rate of oxygen (CMRO2) consumption. We investigated hemispherical dependence of the method in three healthy volunteers as well as its potential for mapping neuronal activity associated with finger tapping in one healthy volunteer. Our findings were consistent with previous results, demonstrating higher CMRO2 values in gray compared to white matter. Evaluation of left/right hemispheric CMRO2 values without sensomotoric stimulation demonstrated hemispherical independence of the technique. The finger-tapping experiment demonstrated increased 17O-signal in the stimulated sensorimotor cortex and adjacent brain tissue, indicating that dynamic 17O-MRI may permit visualization of physiological neuronal activity.

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