Abstract #0473

In vivo NAD+/NADH Measurements in the Human Brain using 31P MRS at 4 T and 7 T

Xi Chen¹, Elliot Kuan², Dost Ongur¹, Wei Chen³, and Fei Du¹

¹McLean Hospital; Harvard Medical School, Belmont, MA, United States, ²McLean Hospital, Belmont, MA, United States, ³University of Minnesota, Minneapolis, MN, United States

Nicotinamide adenine dinucleotides play a crucial role in human health, but measuring the redox ratio (NAD+/NADH) in vivo is technically challenging and the confounding effects from UDPG remain unclear. In this study, for the first time we observed that the NAD+/NADH values decreased in 4T proton-decoupling spectra when the UDPG contribution was accounted for as well as confirming the opposite trend at 7T. Furthermore, we revealed different overlapping patterns at 4T and 7T which lead to this result. Finally, individual redox ratio measures with and without UDPG quantification are strongly correlated with one another at both 4T and 7T.

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