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Abstract #0474

Multiplexed Measurement of Multiple Nuclei (M3N) for integrated multi-nuclei imaging and parametric mapping in 23Na and 1H MRI

Yasmin Blunck1,2, Daniel Staeb3, Rebecca K Glarin2,4,5, Bradford A Moffat2,4, Kieran O'Brien6, and Leigh A Johnston1,2
1Department of Biomedical Engineering, University of Melbourne, Parkville, Australia, 2Melbourne Brain Centre Imaging Unit, University of Melbourne, Parkville, Australia, 3MR Research Collaborations, Siemens Healthcare Pty Ltd, Melbourne, Australia, 4Department of Medicine & Radiology, University of Melbourne, Parkville, Australia, 5Department of Radiology, Royal Melbourne Hospital, Parkville, Australia, 6MR Research Collaborations, Siemens Healthcare Pty Ltd, Brisbane, Australia

X-nuclei imaging like sodium MRI offers complementary information to 1H-based imaging. However, its clinical translation is hampered by the significant increase in scan time required for the acquisition of an additional nuclei. Addressing this challenge, this work introduces Multiplexed Measurement of Multiple Nuclei (M3N) sequences and proposes MERINA-MP2RAGE, a multi-nuclei sequence, that embeds sodium MRI in a 1H-MP2RAGE acquisition. The developed sequence was implemented on a 7T MRI and tested in phantom and human in vivo experiments. Merging 1H-MP2RAGE and 23Na-MERINA reduces the total scan time by 40% compared to sequential acquisitions while maintaining uncompromised image quality.

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