Abstract #0474

Multiplexed Measurement of Multiple Nuclei (M3N) for integrated multi-nuclei imaging and parametric mapping in 23Na and 1H MRI

Yasmin Blunck^1,2, Daniel Staeb³, Rebecca K Glarin^2,4,5, Bradford A Moffat^2,4, Kieran O'Brien⁶, and Leigh A Johnston^1,2

¹Department of Biomedical Engineering, University of Melbourne, Parkville, Australia, ²Melbourne Brain Centre Imaging Unit, University of Melbourne, Parkville, Australia, ³MR Research Collaborations, Siemens Healthcare Pty Ltd, Melbourne, Australia, ⁴Department of Medicine & Radiology, University of Melbourne, Parkville, Australia, ⁵Department of Radiology, Royal Melbourne Hospital, Parkville, Australia, ⁶MR Research Collaborations, Siemens Healthcare Pty Ltd, Brisbane, Australia

X-nuclei imaging like sodium MRI offers complementary information to ¹H-based imaging. However, its clinical translation is hampered by the significant increase in scan time required for the acquisition of an additional nuclei. Addressing this challenge, this work introduces Multiplexed Measurement of Multiple Nuclei (M³N) sequences and proposes MERINA-MP2RAGE, a multi-nuclei sequence, that embeds sodium MRI in a ¹H-MP2RAGE acquisition. The developed sequence was implemented on a 7T MRI and tested in phantom and human in vivo experiments. Merging ¹H-MP2RAGE and ²³Na-MERINA reduces the total scan time by 40% compared to sequential acquisitions while maintaining uncompromised image quality.

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