Abstract #0475

Dynamic assessment of early metabolic perturbations in glioma-bearing mice using denoised 2H-MRS

Rui V Simoes¹, Javier Istúriz², Jonas L Olesen³, Sune N Jespersen³, and Noam Shemesh¹

¹Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, ²Neos Biotec, Pamplona, Spain, ³Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

As our understanding of cancer metabolism advances, novel methods are needed to dynamically assess its heterogeneity in preclinical models, with high temporal resolution. Here we show the feasibility of dynamic ²H-MRS in glioma-bearing mice to monitor glucose metabolism with <3s resolution. This was achieved with a new ²H/¹H RF coil design for the mouse brain and a novel application of Marchenko–Pastur denoising. We are now adapting this methodology to ²H-MRSI, with high spatial resolution.

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