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Abstract #0475

Dynamic assessment of early metabolic perturbations in glioma-bearing mice using denoised 2H-MRS

Rui V Simoes1, Javier Istúriz2, Jonas L Olesen3, Sune N Jespersen3, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Neos Biotec, Pamplona, Spain, 3Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

As our understanding of cancer metabolism advances, novel methods are needed to dynamically assess its heterogeneity in preclinical models, with high temporal resolution. Here we show the feasibility of dynamic 2H-MRS in glioma-bearing mice to monitor glucose metabolism with <3s resolution. This was achieved with a new 2H/1H RF coil design for the mouse brain and a novel application of Marchenko–Pastur denoising. We are now adapting this methodology to 2H-MRSI, with high spatial resolution.

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