Abstract #0476

Combining 1H MRS with deuterium labeled glucose: A new strategy to assess dynamics of neural metabolism in vivo

Laurie J Rich¹, Puneet Bagga¹, Gabor Mizsei¹, Mitchell D Schnall¹, John A Detre², Mohammad Haris³, and Ravinder Reddy¹

¹Radiology, University of Pennyslvania, Philadelphia, PA, United States, ²Neurology, University of Pennyslvania, Philadelphia, PA, United States, ³Research Branch, Qatar University, Doha, Qatar

Proton magnetic resonance spectroscopy (¹H MRS) is a powerful technique capable of detecting a range of endogenous metabolites, but with currently existing approaches does not enable tracking of metabolic fluxes and pathways. We report a new strategy which utilizes ¹H MRS in conjunction with administration of deuterium (²H) labeled glucose to track downstream labeling of neural metabolites. Since ²H is invisible on ¹H MRS, replacement of ¹H with ²H leads to an overall reduction in ¹H MRS signal for the corresponding metabolites. Therefore, this approach makes it possible to monitor neural metabolism using conventional and widely available ¹H MRS methodologies.

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