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Abstract #0476

Combining 1H MRS with deuterium labeled glucose: A new strategy to assess dynamics of neural metabolism in vivo

Laurie J Rich1, Puneet Bagga1, Gabor Mizsei1, Mitchell D Schnall1, John A Detre2, Mohammad Haris3, and Ravinder Reddy1
1Radiology, University of Pennyslvania, Philadelphia, PA, United States, 2Neurology, University of Pennyslvania, Philadelphia, PA, United States, 3Research Branch, Qatar University, Doha, Qatar

Proton magnetic resonance spectroscopy (1H MRS) is a powerful technique capable of detecting a range of endogenous metabolites, but with currently existing approaches does not enable tracking of metabolic fluxes and pathways. We report a new strategy which utilizes 1H MRS in conjunction with administration of deuterium (2H) labeled glucose to track downstream labeling of neural metabolites. Since 2H is invisible on 1H MRS, replacement of 1H with 2H leads to an overall reduction in 1H MRS signal for the corresponding metabolites. Therefore, this approach makes it possible to monitor neural metabolism using conventional and widely available 1H MRS methodologies.

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