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Abstract #0477

Detection of Multiple Nucleotide Sugars Including Uridine Diphosphate Hexoses and N-Acetyl Hexosamines in Human Brain by 31P MRS at 7T

Jimin Ren1,2, Craig R Malloy1,2,3, and A Dean Sherry1,2,4
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3VA North Texas Health Care System, Dallas, TX, United States, 4Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States

A variety of nucleotide sugars (NS) are required for glycosylation of proteins and lipids to enhance and diversify cellular functions. The current 7T 31P MRS study, for the first time, reports the detection of four different NS species in human brain in vivo. They are tentatively assigned to UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, and UDP-N-acetylgalactosamine, collectively denoted as UDP(G). These UDP(G) species are responsible for the observation of a “quartet-like” signal at -9.8 ppm, which cannot be explained by the presence of only a single UDP(G) species such as UDP-glucose (as expected to be a simple doublet).

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