Abstract #0481

Direct 17O-ZTE-MRI reveals decreased cerebral metabolic rate of oxygen consumption in a murine model of amyloidosis

Celine Baligand^1,2, Jean-Baptiste Perot^1,2, Didier Thenadey^1,2, Julien Flament^1,2, Marc Dhenain^1,2, and Julien Valette^1,2

¹Molecular Imaging Research Center (MIRCen), Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Fontenay-aux-Roses, France, ²Neurodegenerative Diseases Laboratory (UMR 9199), Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay, Fontenay-aux-Roses, France

The cerebral metabolic rate of oxygen consumption (CMRO₂) is an important metric of brain metabolism. It is of particular interest in preclinical studies of Alzheimer’s disease, where amyloidosis has been associated with impaired mitochondrial function. CMRO₂ can be measured by direct ¹⁷O-MRI of H₂¹⁷O signal changes during inhalation of ¹⁷O-labeled oxygen gas. In this study, we used 3D zero echo time ¹⁷O-(ZTE-)MRI at 11.7T to measure CMRO₂ in the APP/PS1_dE9 mouse model of amyloidosis and show that it is significantly lower than in control mice.

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