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Abstract #0481

Direct 17O-ZTE-MRI reveals decreased cerebral metabolic rate of oxygen consumption in a murine model of amyloidosis 

Celine Baligand1,2, Jean-Baptiste Perot1,2, Didier Thenadey1,2, Julien Flament1,2, Marc Dhenain1,2, and Julien Valette1,2
1Molecular Imaging Research Center (MIRCen), Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Fontenay-aux-Roses, France, 2Neurodegenerative Diseases Laboratory (UMR 9199), Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay, Fontenay-aux-Roses, France

The cerebral metabolic rate of oxygen consumption (CMRO2) is an important metric of brain metabolism. It is of particular interest in preclinical studies of Alzheimer’s disease, where amyloidosis has been associated with impaired mitochondrial function. CMRO2 can be measured by direct 17O-MRI of H217O signal changes during inhalation of 17O-labeled oxygen gas. In this study, we used 3D zero echo time 17O-(ZTE-)MRI at 11.7T to measure CMRO2 in the APP/PS1dE9 mouse model of amyloidosis and show that it is significantly lower than in control mice.

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