Abstract #0482

Regional Analysis of CMRO2 in Human Brain Using Dynamic 17O-MRI

Hao Song¹, Yanis Taege¹, Johannes Fischer¹, Ali Caglar Özen^1,2, and Michael Bock^1,2

¹Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ²German Consortium for Translational Cancer Research (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this work, regional quantification of the cerebral metabolic rate of oxygen consumption (CMRO₂) was performed using dynamic ¹⁷O-MRI with inhalation of isotope-enriched ¹⁷O₂. First, global mean CMRO₂ values were determined in cortical grey matter and white matter. Then, local CMRO₂was investigated in frontal, parietal and occipital areas, respectively. The results were in good agreement with previously reported PET values especially for the cortical grey matter. For regional analysis, the CMRO₂ values show good consistency across the white matter and in both frontal and parietal cortical grey matter.

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