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Abstract #0482

Regional Analysis of CMRO2 in Human Brain Using Dynamic 17O-MRI

Hao Song1, Yanis Taege1, Johannes Fischer1, Ali Caglar Özen1,2, and Michael Bock1,2
1Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2German Consortium for Translational Cancer Research (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this work, regional quantification of the cerebral metabolic rate of oxygen consumption (CMRO2) was performed using dynamic 17O-MRI with inhalation of isotope-enriched 17O2. First, global mean CMRO2 values were determined in cortical grey matter and white matter. Then, local CMRO2 was investigated in frontal, parietal and occipital areas, respectively. The results were in good agreement with previously reported PET values especially for the cortical grey matter. For regional analysis, the CMRO2 values show good consistency across the white matter and in both frontal and parietal cortical grey matter.

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