Abstract #0484

Fast In Vivo 23Na Imaging and T2* Mapping Using Non-Localized 2D FID Magnetic Resonance Spectroscopic Imaging at 3 T

Ahmad Alhulail^1,2, Pingyu Xia¹, Xin Shen³, Miranda Nichols¹, Srijyotsna Volety¹, Nicholas Farley¹, Armin M Nagel⁴, Ulrike Dydak^1,5, and Uzay E Emir^1,3

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Department of Radiology and Medical Imaging, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, ³Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ⁴Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁵Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Sodium signal decays quickly and bi-exponentially, which make T₂ relaxation fitting and absolute quantification challenging. Estimating T₂ with enough data points using multiple echoes requires an impractical acquisition time. Alternatively, we propose a fast sodium 2D-FID-MRSI sequence to collect the decaying signal with a high sampling frequency (625 Hz) starting at 0.55 ms within only 4 minutes at 3T. We demonstrate an absolute concentration map and separate maps of fast (mean: 0.4 ±0.4 ms) and slow (mean: 19.6 ±5.7 ms) T₂* components from human calf muscles, showing that rapid data collection for T₂* correction is feasible with this ²³Na-MRSI method.

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