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Abstract #0484

Fast In Vivo 23Na Imaging and T2* Mapping Using Non-Localized 2D FID Magnetic Resonance Spectroscopic Imaging at 3 T

Ahmad Alhulail1,2, Pingyu Xia1, Xin Shen3, Miranda Nichols1, Srijyotsna Volety1, Nicholas Farley1, Armin M Nagel4, Ulrike Dydak1,5, and Uzay E Emir1,3
1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Department of Radiology and Medical Imaging, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, 3Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 4Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 5Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Sodium signal decays quickly and bi-exponentially, which make T2 relaxation fitting and absolute quantification challenging. Estimating T2 with enough data points using multiple echoes requires an impractical acquisition time. Alternatively, we propose a fast sodium 2D-FID-MRSI sequence to collect the decaying signal with a high sampling frequency (625 Hz) starting at 0.55 ms within only 4 minutes at 3T. We demonstrate an absolute concentration map and separate maps of fast (mean: 0.4 ±0.4 ms) and slow (mean: 19.6 ±5.7 ms) T2* components from human calf muscles, showing that rapid data collection for T2* correction is feasible with this 23Na-MRSI method.

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