Abstract #0485

Multi-nuclear MRI identifies elevated skin sodium in adults with salt-sensitive blood pressure

Kalen J. Petersen¹, Maria Garza¹, Cassandra Reynolds², Deepak Gupta², Manus J. Donahue^1,3,4, and Rachelle Crescenzi¹

¹Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, ²Cardiology, Vanderbilt University Medical Center, Nashville, TN, United States, ³Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States

Salt sensitive blood pressure (SSBP) is a cardiovascular disease risk factor, yet clinically-feasible biomarkers of SSBP have not been developed. We tested the hypothesis that peripheral tissue sodium content (TSC), measured with ²³Na-MRI, is higher in persons with vs. without SSBP (n=39 total; age=29.4±7.4 years; sex=21/18 F/M). SSBP was confirmed by independent measurement of BP increase >5 mmHg after high-salt diet compared to low-salt diet. SSBP participants (n=13) had elevated leg skin TSC (p=0.04), and TSC was inversely correlated with leg fat-fraction (ρ=-0.57; p<0.001). Findings suggest that multi-nuclear ²³Na/¹H-MRI could provide a radiological screening tool for SSBP.

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