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Abstract #0486

Respiratory motion compensation for human cardiac 23Na MRI

Johanna Lott1,2, Armin M. Nagel1,3,4, Sebastian C. Niesporek1, Thoralf Niendorf5,6, Peter Bachert1,2, Mark E. Ladd1,2,7, and Tanja Platt1
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 5Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 6MRI. TOOLS GmbH, Berlin, Germany, 7Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Sodium (23Na) ion distribution plays a fundamental role in biological processes, in particular in myocardial function. 23Na MRI provides noninvasive information about the total tissue sodium concentration. However, short relaxation times, low signal-to-noise ratio, breathing and heart motion render quantitative cardiac 23Na MRI challenging and result in long acquisition times. We present a method to compensate for respiratory motion in 23Na MRI by adding a linear phase in k-space with the goal to determine myocardial tissue sodium concentration. This enables a reduced measurement time for quantitative cardiac 23Na MRI compared to retrospective sorting into one respiratory state.

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