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Abstract #0488

Studying Human Plantar Flexor Muscles at Low-Intensity Exercise by Interleaving Perfusion 1H MRI with Localised 31P MRS

Fabian Niess1,2, Albrecht Ingo Schmid1,2, Siegfried Trattnig2,3, Ewald Moser1,2, and Martin Meyerspeer1,2
1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Wien, Austria, 2High-Field MR Centre, Medical University of Vienna, Wien, Austria, 3Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria

The purpose of this study is to show the effect of low-intensity exercise on localised 31P MR spectra and 1H images of human muscle. It was determined which PCr depletion is sufficient for quantifying the PCr recovery time constant (τPCr), while incurring minimal pH drop in a predominantly glycolytic muscle. PCr depletion during exercise was measured, PCr recovery was fitted and pH was quantified with dynamic localised 31P MRS, while perfusion and BOLD 1H images were simultaneously acquired in time-resolved measurements. Prolongation of τPCr with acidification was confirmed, while very short τPCr was found with neutral and slightly acidic pH.

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