Abstract #0488

Studying Human Plantar Flexor Muscles at Low-Intensity Exercise by Interleaving Perfusion 1H MRI with Localised 31P MRS

Fabian Niess^1,2, Albrecht Ingo Schmid^1,2, Siegfried Trattnig^2,3, Ewald Moser^1,2, and Martin Meyerspeer^1,2

¹Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Wien, Austria, ²High-Field MR Centre, Medical University of Vienna, Wien, Austria, ³Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria

The purpose of this study is to show the effect of low-intensity exercise on localised ³¹P MR spectra and ¹H images of human muscle. It was determined which PCr depletion is sufficient for quantifying the PCr recovery time constant (τ_PCr), while incurring minimal pH drop in a predominantly glycolytic muscle. PCr depletion during exercise was measured, PCr recovery was fitted and pH was quantified with dynamic localised ³¹P MRS, while perfusion and BOLD ¹H images were simultaneously acquired in time-resolved measurements. Prolongation of τ_PCr with acidification was confirmed, while very short τ_PCr was found with neutral and slightly acidic pH.

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