Functional magnetic resonance spectroscopy can non-invasively measure changes in local concentrations of neurometabolites and has been used to demonstrate changes in lactate and glutamate levels in response to visual stimulation. However, whether the neurometabolite response scales with the level of neuronal stimulation like the BOLD response, has not been extensively investigated. We here show that lactate, but not glutamate levels, change dependent on visual contrast levels (baseline, 10%, 100% contrast). Although we also demonstrate a significant contrast dependence in the BOLD response, we do not find a significant association between the lactate response and the BOLD response.
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