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Abstract #0489

A 7T interleaved fMRS and fMRI study on visual contrast dependency in the human brain.

Anouk Schrantee1, Chloe Najac2, Chris Jungerius2, Aart J Nederveen1, Vincent O Boer3, Wietske van der Zwaag4, Silvia Mangia5, and Itamar Ronen2
1Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 4Spinoza Centre for Neuroimaging, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands, 5Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Functional magnetic resonance spectroscopy can non-invasively measure changes in local concentrations of neurometabolites and has been used to demonstrate changes in lactate and glutamate levels in response to visual stimulation. However, whether the neurometabolite response scales with the level of neuronal stimulation like the BOLD response, has not been extensively investigated. We here show that lactate, but not glutamate levels, change dependent on visual contrast levels (baseline, 10%, 100% contrast). Although we also demonstrate a significant contrast dependence in the BOLD response, we do not find a significant association between the lactate response and the BOLD response.

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