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Abstract #0491

Simultaneous ultra-short TE-MRS in two voxels using a SPECIAL sequence with Hadamard encoding

Masoumeh Dehghani1,2, Richard Edden 3, and Jamie Near1,2
1McGill University, Montreal, QC, Canada, 2Centre d'Imagerie Cérébrale, Montreal, QC, Canada, 3Johns Hopkins University, Baltimore, MD, United States

The spin echo, full Intensity acquired localized (SPECIAL) sequence consists of a localized spin-echo, preceded by an alternating ISIS pre-inversion for voxel localization. In this study we modified the SPECIAL sequence to simultaneously localize the signal at two different positions. The technique relies on a four-step inversion scheme involving two different inversion positions, followed by a Hadamard encoding reconstruction. Comparing the in vivo performance of dual-SPECIAL sequence to the conventional SPECIAL sequence demonstrated that the dual-Special sequence provides simultaneous metabolite profile from two different regions, reducing the acquisition time by a factor of two, and without any penalty in SNR.

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