Abstract #0493

Quantitative Multiple Quantum Filtered Sodium MRI and [18F]-FET-PET: Complementary Imaging Techniques for the Study of Cerebral Gliomas

Wieland A Worthoff¹, Aliaksandra Shymanskaya², Karl-Josef Langen^1,3,4, and N. Jon Shah^1,2,4,5

¹Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich GmbH, Jülich, Germany, ²Institute of Neuroscience and Medicine - 11, Forschungszentrum Jülich GmbH, Jülich, Germany, ³Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, ⁴Section JARA-Brain, Jülich-Aachen Research Alliance, Aachen, Germany, ⁵Department of Neurology, RWTH Aachen University, Aachen, Germany

A cohort of patients with untreated cerebral gliomas underwent consecutive [¹⁸F]-FET-PET and sodium MRI exams. It is shown that quantitative results from multiple quantum filtered sodium MRI using the enhanced SISTINA sequence offer access to the metabolic properties of tumours beyond what is observed by [¹⁸F]-FET-PET alone, thus presenting the potential to serve as an additional marker in tumour diagnostics.

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