Meeting Banner
Abstract #0494

Cerebral energy metabolism and neurotransmission in a schizophrenia mouse model: a combined 1H-[13C] MRS and 13C MRS study at 14.1T

Bernard Lanz1, Radek Skupienski2,3,4, Kim Q Do2, and Lijing Xin3
1LIFMET, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Prilly, Switzerland, 3Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 4HES-SO, University of Applied Sciences of Western Switzerland, HEIA-FR, Institute of Chemical Technology, Fribourg, Switzerland

In this study, we applied interleaved localized 1H-[13C]-MRS and direct 13C MRS with polarization transfer to characterize brain energy metabolism in the early development of a GCLM-KO mouse model with infusion of [2-13C]acetate. This strategy enabled to measure simultaneously the [2-13C]acetate input function, glutamate and glutamine C4 and C3 enrichment and pool size changes. Two-compartment metabolic modelling was then applied to characterize mitochondrial metabolism and glutamate/glutamine cycling and compare it to a control group.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here