Abstract #0494

Cerebral energy metabolism and neurotransmission in a schizophrenia mouse model: a combined 1H-[13C] MRS and 13C MRS study at 14.1T

Bernard Lanz¹, Radek Skupienski^2,3,4, Kim Q Do², and Lijing Xin³

¹LIFMET, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Prilly, Switzerland, ³Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁴HES-SO, University of Applied Sciences of Western Switzerland, HEIA-FR, Institute of Chemical Technology, Fribourg, Switzerland

In this study, we applied interleaved localized ¹H-[¹³C]-MRS and direct ¹³C MRS with polarization transfer to characterize brain energy metabolism in the early development of a GCLM-KO mouse model with infusion of [2-¹³C]acetate. This strategy enabled to measure simultaneously the [2-¹³C]acetate input function, glutamate and glutamine C4 and C3 enrichment and pool size changes. Two-compartment metabolic modelling was then applied to characterize mitochondrial metabolism and glutamate/glutamine cycling and compare it to a control group.

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