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Abstract #0496

Multimodal assessment of brain energy metabolism in a rat model of hepatic encephalopathy using 1H-MRS and 18F-FDG PET – a pilot study

Jessie Mosso1,2, Carole Poitry-Yamate1, Dunja Simicic1,2, Mario Lepore1, Cristina Cudalbu1, and Bernard Lanz2
1Center for biomedical imaging (CIBM), EPFL, Lausanne, Switzerland, 2Laboratory for functional and metabolic imaging (LIFMET), EPFL, Lausanne, Switzerland

Hepatic encephalopathy (HE) is a severe complication of chronic liver disease which drastically affects patient lives. Its underlying mechanisms are still unknown and energy metabolism studies are of key interest. Here, we combined 18F-FDG PET and 1H-MRS and found a 2-fold decrease in brain glucose uptake in a rat model of HE compared to SHAM rats, associated with a previously reported increase in brain glutamine and decrease in osmolytes. Although the difference in glucose uptake measured by PET results from a combination of brain and systemic effects, this finding provides a new perspective on HE pathophysiology.

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