Abstract #0499

Understanding the magnetization transfer pathway for water-based detection of the aliphatic protons in glycogen

Yang Zhou^1,2, Peter C.M. van Zijl^1,2, Jiadi Xu^1,2, and Nirbhay N. Yadav^1,2

¹The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional, Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Recently a new MRI method was developed for the sensitivity enhanced detection of glycogen based on magnetization transfer between glycogen aliphatic protons and water, yet the mechanism of this transfer pathway is still not well understood. Here, we show that the magnetization transfer occurs via the relayed-NOE (rNOE) CEST effect. A theoretical model is proposed to quantitatively describe the rNOE signal in these magnetization transfer MRI experiments. This study provides insight into the rNOE mechanism that commonly occurs in magnetization transfer MRI on systems such as proteins and carbohydrate polymers.

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