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Abstract #0498

Orientation dependence of inhomogeneous magnetization transfer and dipolar order relaxation time in a phospholipid bilayer sample

Sarah Rosemary Morris1,2,3, Rebecca Frederick1, Alex L MacKay1,2,4, Cornelia Laule1,2,3,5, and Carl A. Michal1
1Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4UBC MRI Research Centre, Vancouver, BC, Canada, 5Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Inhomogeneous magnetization transfer ratio (ihMTR) is reported to have significant orientation dependence in the brain, likely due to the anisotropy of dipolar couplings between methylene protons on the oriented lipids in myelin bilayers. We measured the orientation dependence of linewidth, dipolar relaxation time (T1D) and ihMTR in an aligned phospholipid bilayer sample at 9.4T. ihMTR was maximized when the bilayers were parallel to B0 and minimized near the magic angle (~54.7°) despite the fact that T1D is maximized there. This is in contrast to previous in vivo results which show maximal ihMTR for bilayers perpendicular to B0.

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