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Abstract #0518

Perfusion Quantification Validation on a Numerical Vascular Network of the Kidney: Traditional Kety’s Method vs Quantitative Transport Mapping

Liangdong Zhou1, Qihao Zhang1,2, Pascal Spincemaille1, Thanh D Nguyen1, John Morgan1, Weiying Dai1, Ajay Gupta1, Martin R Prince1, and Yi Wang1,2
1Weill Medical College of Cornell University, New York, NY, United States, 2Cornell University, Ithaca, NY, United States

Perfusion quantification is important for the diagnosis of many diseases. Validation of perfusion quantification methods remains challenging due to the various assumptions and lack of the ground truth. We built a numerical phantom of microvascular network in the kidney. In the phantom, the ground truth blood velocity and flow were computed from Navier-Stokes equation. Tracer concentration was simulated based on the mass transport equation. Comparison between Kety's method and our recently proposed AIF-free QTM method was performed using the numerical phantom. It turns out that QTM method reduces the flow error by more than 3 folds compare with Kety's method.

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