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Abstract #0527

Adiabatic Inversion and T1 Relaxation of Bovine White Matter

Luke A. Reynolds1, Alex L. MacKay1,2,3, and Carl A. Michal1
1Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3MRI Research Centre, University of British Columbia, Vancouver, BC, Canada

Adiabatic pulses are commonly used in clinical MRI due to their insensitivity to B1 inhomogeneity and uniform flip angle over a selected bandwidth. When applied to white matter, they are generally assumed to saturate the magnetization of the non-aqueous protons in myelin. We performed adiabatic inversion recovery experiments on bovine brain in vitro using a solid state NMR spectrometer to directly observe the effects of adiabatic inversions on the non-aqueous signal. Substantial non-aqueous magnetization remains after typical adiabatic pulses. The state of the non-aqueous magnetization seriously impacts measurement of T1, yielding values dependent on the form of inversion pulse used.

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