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Abstract #0529

Variable Flip Angle 3D Echo Planar Time-Resolved Imaging (vFA 3D-EPTI) for Fast Multi-Compartment Quantitative Mapping

Zijing Dong1,2, Fuyixue Wang1,3, Kwok-Shing Chan4, Timothy G. Reese1, Berkin Bilgic1, José P. Marques4, and Kawin Setsompop1,3
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 4Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands

Multi-compartment models have been developed to detect the microstructure properties of brain tissue using multi-modal MRI, but are limited by the long scan time of multi-contrast multi-parametric acquisition. In this work, a novel variable flip angle EPTI (vFA 3D-EPTI) technique is developed to quickly acquire rich multi-contrast information for multi-compartment analysis. The optimized ‘temporal variant CAIPI’ sampling was used, and an augmented subspace reconstruction with multi-compartment modelling is also developed to accurately reconstruct complex signal evolution. Through this approach, myelin water fraction, proton density, multi-compartment T1, T2* maps can be acquired simultaneously in 12 minutes at 1-mm isotropic resolution.

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