Multi-compartment models have been developed to detect the microstructure properties of brain tissue using multi-modal MRI, but are limited by the long scan time of multi-contrast multi-parametric acquisition. In this work, a novel variable flip angle EPTI (vFA 3D-EPTI) technique is developed to quickly acquire rich multi-contrast information for multi-compartment analysis. The optimized ‘temporal variant CAIPI’ sampling was used, and an augmented subspace reconstruction with multi-compartment modelling is also developed to accurately reconstruct complex signal evolution. Through this approach, myelin water fraction, proton density, multi-compartment T1, T2* maps can be acquired simultaneously in 12 minutes at 1-mm isotropic resolution.
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