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Abstract #0531

Correlation Time as a New MRI Contrast

Hassaan Elsayed1,2, Jouni Karjalainen1,2, Nina Hänninen1,3, Isabel Stavenuiter3, Stefan Zbyn1,4, Mikko Nissi1,3, Miika T. Nieminen1,2,5, and Matti Hanni1,2,5
1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 4Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

In this study, we determined correlation time ($$$\tau_c$$$ ), a parameter that we propose as MRI contrast indicative of the structure of articular cartilage. $$$T_{1\rho}$$$ dispersion data were acquired from intact patellar bovine cartilage samples and $$$\tau_c$$$ maps were obtained by fitting a Lorentzian model function to the $$$T_{1\rho}$$$ dispersion. The association between $$$\tau_c$$$ and the tissue properties was assessed by correlation analysis between $$$\tau_c$$$ and histology. The results suggest that the proposed parameter $$$\tau_c$$$ as well as other fitting parameters can reveal cartilage structure. More investigation is needed to establish correlation between $$$\tau_c$$$ and histology.

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