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Abstract #0532

Subvoxel Vascular Imaging of the Midbrain Using USPIO-Enhanced MRI

Sagar Buch1, Ying Wang2, Pavan K. Jella1, Min-Gyu Park3, Yongsheng Chen1,4, Jiani Hu1, Yulin Ge5, Kamran Shah1, and E. Mark Haacke1,2
1Department of Radiology, Wayne State University, Detroit, MI, United States, 2Magnetic Resonance Innovations, Inc., Detroit, MI, United States, 3Department of Neurology, Pusan National University School of Medicine, Yangsan, Korea, Republic of, 4Department of Neurology, Wayne State University, Detroit, MI, United States, 5Department of Radiology, New York University School of Medicine, New York, NY, United States

We demonstrate the utility of low dose Ferumoxytol in microvasculature imaging of the midbrain using susceptibility weighted imaging (SWI). Mapping the brain’s vasculature has implications for understanding the etiology of many neurovascular and neurodegenerative diseases such as Parkinson’s disease. By administering this strongly paramagnetic agent, SWI was able to visualize both arteries and veins; and its sensitivity to detect sub-voxel vessels increased tremendously. However, the use of Ferumoxytol exacerbates the signal loss of large vessels, confounding the ability to visualize nearby smaller vessels. Hence, we propose the use of multiple time point SWI to effectively see through the blooming artifacts.

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