We demonstrate the utility of low dose Ferumoxytol in microvasculature imaging of the midbrain using susceptibility weighted imaging (SWI). Mapping the brain’s vasculature has implications for understanding the etiology of many neurovascular and neurodegenerative diseases such as Parkinson’s disease. By administering this strongly paramagnetic agent, SWI was able to visualize both arteries and veins; and its sensitivity to detect sub-voxel vessels increased tremendously. However, the use of Ferumoxytol exacerbates the signal loss of large vessels, confounding the ability to visualize nearby smaller vessels. Hence, we propose the use of multiple time point SWI to effectively see through the blooming artifacts.
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