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Abstract #0543

Quantification of T1 and relative proton density in the brain ultrashort-T2* component

Nikhil Deveshwar1, Emil Ljungberg2, Misung Han1, and Peder E. Z. Larson1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Neuroimaging, King’s College London, London, United Kingdom

This study presents a VFA approach for quantification of T1 and relative proton density of the brain ultrashort-T2* component. Measured T1 values corresponding to the ultrashort-T2* component were lower compared to T1 values corresponding to long-T2* components, and did not exhibit gray/white matter differences. Qualitatively, ultrashort-T2* component fraction maps showed better gray/white matter contrast and clearer white matter structure delineation which we expect to be a more accurate representation of relative proton density. These results show that added VFA T1 encoding in characterization of the brain ultrashort-T2* component can more accurately differentiate white matter anatomy.

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