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Abstract #0544

Feasibility for MR Elastography to Meet Unmet Need in Intracerebral Hemorrhage Surgical Planning

Robert Moskwa1, Dipul Chawla2, Corinne Henak2, Azam Ahmed3, and Walter Block1
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 3Neurological Surgery, University of Wisconsin-Madison, Madison, WI, United States

It is hypothesized that the proper surgical approach for intracerebral hemorrhage (ICH) victims should depend on clot rigidity. Neurosurgical experience indicates that brain clot rigidity varies across patients and varies spatially and temporally within each patient. We hypothesize that the wide range of clot rigidity in ICH will allow MR elastography (MRE) techniques to depict the heterogeneity over a wide dynamic range of rigidity. Longitudinal MRE, ultrasound elastography, and mechanical compression testing were performed on large ex-vivo swine blood clots. MR elastography shows promise for characterizing the rigidity of intracerebral hemorrhage as indicated by these ex-vivo tests.

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