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Abstract #0545

Measurement of Blood-Brain Barrier Permeability in Human Brain using Magnetization Transfer Effect at 7T.

Sultan Zaman Mahmud1,2, Thomas S. Denney1,2, Ronald J. Beyers2, and Adil Bashir1,2
1Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 2Auburn University MRI Research Center, Auburn, AL, United States

Blood-brain barrier (BBB) plays a very important role in regulating water and nutrients delivery between vascular circulation and central nervous system (CNS). Any disruption in the blood brain barrier may cause the alteration of normal functional activity of the nervous system. The techniques currently available to measure BBB permeability are prone to certain limitations and potential side effects. In this study we demonstrated a non-invasive technique of evaluating BBB permeability using the magnetization transfer (MT) effect on endogenous water labeled by arterial spin labeling (ASL) technique as a perfusion tracer.

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