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Abstract #0547

Improved Volumetric Myelin Imaging in Human Brain Utilizing Inversion Recovery Prepared Ultrashort Echo Time with Complex Echo Subtraction

Hyungseok Jang1, Zhao Wei1, Mei Wu1, Yajun Ma1, Eric Chang1,2, Jody Corey-Bloom1, and Jiang Du1
1University of California, San Diego, San Diego, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States

Myelin accelerates neural signaling in the central and peripheral nervous systems. Ultrashort echo time (UTE)-based imaging techniques have been proposed for direct capture of magnetic resonance (MR) signal from myelin lipid protons with extremely short T2* (~0.3 ms). To suppress signal from long T2 water components and thereby improve myelin imaging, inversion recovery (IR)-based UTE techniques have been proposed. In this study, we explored the efficacy and feasibility of qualitative myelin imaging in vivo combining dual-echo IR-UTE with complex echo subtraction.

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