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Abstract #0548

Post-mortem Diffusion MRI Analysis of Neuronal Pathways in the Human Hippocampus

Choong Heon Lee1, Jing Li2, Yulin Ge1, Timothy M Shepherd1, Youssef Zaim Wadghiri1, Jiangyang Zhang1, and David W Nauen3
1Radiology, New York University School of Medicine, New York, NY, United States, 2Peking Union Medical College Hospital, Beijing, China, 3Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

High-resolution diffusion MRI data of post-mortem adult human hippocampus specimens were acquired and compared to histology to identify major axonal pathways in the hippocampus. The complex microstructural organization in the hippocampus made it difficult to resolve axonal pathways based on conventional diffusion tensor data. In comparison, neurite density map using the NODDI toolbox revealed the locations of the perforant path, mossy fibers, and Schaffer collaterals confirmed by histology. We were able to reconstruct the fimbria/alveus and perforant pathways using tractography, and the results resembled in vivo results from the HCP dataset. Other pathways in the hippocampus remained difficult to delineate.

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