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Abstract #0553

A novel MRI-based quantitative water content atlas of the human brain

N. Jon Shah1,2,3, Zaheer Abbas1, Dominik Ridder1, Markus Zimmermann1, and Ana-Maria Oros-Peusquens1
1Medical Imaging Physics, Institute of Neuroscience and Medicine 4, Jülich, Germany, 2Institute of Neuroscience and Medicine 11, INM 11, JARA, Jülich, Germany, 3Department of Neurology, Faculty of Medicine, Aachen, Germany

Measurement of quantitative, tissue-specific MR properties such as water content or relaxation times using quantitative-MRI at clinical field strength is a well-explored topic. However, none of the commonly used standard brain atlases, e.g., MNI or JHU, provide quantitative information. Utilising the framework of quantitative-MRI of the brain, this work reports on the development of the first quantitative in-vivo water content atlas based on twenty healthy volunteers datasets. Additionally, water content maps from patients with pathological changes in the brain were compared voxel-wise. These results suggest that quantitative-MRI in combination with water content atlas allows careful and quantitative interpretation of disease.

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