Although there is no lymphatic system in the CNS, there seems to be a mechanism to remove macro molecules from the brain. CSF and ISF are thought to be parts of this pathway, but the details are not known. In this study, MR signal of the extracellular water, including CSF, was decomposed into components with distinct T2’s, to estimate content of macromolecules in each compartment. Assuming that protein content is relatively high along the clearance pathway, it might be possible to have some insight about this pathway from the obtained T2 map.
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