Abstract #0558

A five-minute multi-parametric high-resolution whole-brain MR-STAT exam: first results from a clinical trial

Stefano Mandija^1,2, Federico D'Agata^1,3, Hongyan Liu^1,2, Oscar van der Heide^1,2, Beyza Koktas², Cornelis A.T. van den Berg^1,2, Jeroen Hendrikse², Anja van der Kolk², and Alessandro Sbrizzi^1,2

¹Computational Imaging Group for MR diagnostic and therapy, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Neurosciences, University of Turin, Turin, Italy

MR-STAT is a recently developed technique which aims at reconstructing multi-parametric quantitative maps (T1, T2, PD, etc.) from a short cartesian acquisition. Previous research efforts have focused on the feasibility of the MR-STAT framework from a technical point of view. In this work, we present the implementation of a five-minute long high-resolution whole-brain MR-STAT protocol in a clinical trial and show the first results obtained from nine subjects. Synthetically generated contrast images as well as quantitative parametric maps show the robustness and the practical feasibility of the 5 minute long comprehensive MR-STAT protocol.

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