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Abstract #0558

A five-minute multi-parametric high-resolution whole-brain MR-STAT exam: first results from a clinical trial

Stefano Mandija1,2, Federico D'Agata1,3, Hongyan Liu1,2, Oscar van der Heide1,2, Beyza Koktas2, Cornelis A.T. van den Berg1,2, Jeroen Hendrikse2, Anja van der Kolk2, and Alessandro Sbrizzi1,2
1Computational Imaging Group for MR diagnostic and therapy, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Neurosciences, University of Turin, Turin, Italy

MR-STAT is a recently developed technique which aims at reconstructing multi-parametric quantitative maps (T1, T2, PD, etc.) from a short cartesian acquisition. Previous research efforts have focused on the feasibility of the MR-STAT framework from a technical point of view. In this work, we present the implementation of a five-minute long high-resolution whole-brain MR-STAT protocol in a clinical trial and show the first results obtained from nine subjects. Synthetically generated contrast images as well as quantitative parametric maps show the robustness and the practical feasibility of the 5 minute long comprehensive MR-STAT protocol.

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