Abstract #0567

Low-Dose, High-Temporal-Resolution Dynamic Contrast Enhanced MRI With Dynamic T1 Mapping Using Multitasking: An Initial Study on Breast Cancer

Nan Wang^1,2, Yibin Xie¹, Lixia Wang^1,3, Sen Ma^1,2, Stephen L. Shiao⁴, Anthony G. Christodoulou¹, and Debiao Li^1,2

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Beijing Chaoyang Hospital, Beijing, China, ⁴Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

DCE MRI is a well-accepted tool in the management of breast cancer, but continues to face technical challenges and concerns regarding gadolinium deposition. In this work, we proposed a novel Multitasking DCE technique, which enables adequate breast coverage, 0.9-mm isotropic spatial resolution, 1.5-s temporal resolution, dynamic T1 mapping throughout all DCE phases, and reduced dose of 0.02mmol/kg for the imaging of breast cancer. The in vivo studies demonstrated that the low-dose Multitasking DCE showed equivalent tumor delineation compared to standard DCE. The quantitative DCE parameters were repeatable in vivo and significantly different between normal breast and breast cancer.

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