Abstract #0574

The additive value of quantitative contralateral background parenchymal enhancement for the prediction of residual disease in the I-SPY 2 TRIAL

Wen Li¹, Natsuko Onishi¹, Vignesh Arasu¹, David C. Newitt¹, Alex Nguyen¹, Jessica Gibbs¹, Lisa J. Wilmes¹, Ella F. Jones¹, John Kornak¹, Bonnie N. Joe¹, The I-SPY 2 Investigator Network², Laura J. Esserman¹, and Nola M. Hylton¹

¹University of California, San Francisco, San Francisco, CA, United States, ²'Quantum Leap Healthcare Collaborative, San Francisco, CA, United States

This study tested the additive value of quantitative background parenchymal enhancement (BPE) assessed in the contralateral breast in the prediction of treatment response for patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy (NAC). BPE predictors were added to the prediction models together with functional tumor volume predictors. Our results showed that combined model achieved better prediction for pathologic complete response in HER2-positive HR-negative cancer subtype after 3 weeks of NAC. The additive values of BPE were also observed at inter-regimen (12-week) for triple negatives, and at the pre-surgery for HR-positive subtypes.

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