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Abstract #0578

CARdiac and Placental imaging (CARP) in pregnancy to assess etiology of preeclampsia and predict cardiovascular disease risk in later life

Jana Hutter1, Kathleen Colford1, Anthony Price1, Johannes Steinweg1, Lisa Story1, Kuberan Pushparajah1, Laura McCabe1, Alison Ho2, Adam J Lewandowski3, Joseph Hajnal1, Lucy Chappell2, Pablo Lamata1, and Mary Rutherford1
1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Academic Women's Health, King's College London, London, United Kingdom, 3Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

Pre-eclampsia (PE) is one of the most common, yet serious, complications of pregnancy. Its manifestations during pregnancy -high blood pressure, proteinuria and placental lesions- are associated with both maternal and fetal morbidity and mortality. Maternal symptoms resolve after delivery but a lifelong elevated risk for cardiovascular disease (CVD) remains. The CARP study combines functional placental and fetal MRI with (maternal) cardiovascular MR during pregnancy at the time of maximal stress to the maternal heart, in an attempt to disentangle the complex cardiac and placental interactions in disease etiology and to predict maternal cardiovascular risk in later life.

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