Abstract #0580

Placental MRI: Using a novel ex vivo placental perfusion chamber to validate in vivo magnetic resonance fingerprinting (MRF) relaxometry

Jeffrey N Stout¹, Shahin Rouhani^1,2, Congyu Liao³, Esra Abaci Turk¹, Christopher G Ha¹, Karen Rich⁴, Lawrence L. Wald³, William H. Barth, Jr⁵, Drucilla J. Roberts², Elfar Adalsteinsson⁶, and P. Ellen Grant¹

¹Fetal-Neonatal Neuroimaging & Developmental Sciences Center, Boston Children's Hospital, Boston, MA, United States, ²Department of Pathology, Massachusetts General Hospital, Boston, MA, United States, ³A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ⁴Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁵Maternal-Fetal Medicine, Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, United States, ⁶Institute for Medical Engineering and Science; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States

The placenta is a challenging MRI target. Acquisition schemes developed for other organs, with implicit assumptions about motion, tissue composition and perfusion, should be vetted for applicability to the placenta. We have developed an ex vivo placental perfusion chamber with integrated MRI receive coil for high SNR and imaging acceleration to validate in vivo acquisitions in a controlled environment. Here we examine the effect of flowing spins on MRF relaxometry. We offer evidence that T1 is sensitive to overall fluid volume, while T2 is additionally sensitive spin inflow. Our placental perfusion system appears promising for validating in vivo quantitative MRI.

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