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Abstract #0580

Placental MRI: Using a novel ex vivo placental perfusion chamber to validate in vivo magnetic resonance fingerprinting (MRF) relaxometry

Jeffrey N Stout1, Shahin Rouhani1,2, Congyu Liao3, Esra Abaci Turk1, Christopher G Ha1, Karen Rich4, Lawrence L. Wald3, William H. Barth, Jr5, Drucilla J. Roberts2, Elfar Adalsteinsson6, and P. Ellen Grant1
1Fetal-Neonatal Neuroimaging & Developmental Sciences Center, Boston Children's Hospital, Boston, MA, United States, 2Department of Pathology, Massachusetts General Hospital, Boston, MA, United States, 3A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 4Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 5Maternal-Fetal Medicine, Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, United States, 6Institute for Medical Engineering and Science; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States

The placenta is a challenging MRI target. Acquisition schemes developed for other organs, with implicit assumptions about motion, tissue composition and perfusion, should be vetted for applicability to the placenta. We have developed an ex vivo placental perfusion chamber with integrated MRI receive coil for high SNR and imaging acceleration to validate in vivo acquisitions in a controlled environment. Here we examine the effect of flowing spins on MRF relaxometry. We offer evidence that T1 is sensitive to overall fluid volume, while T2 is additionally sensitive spin inflow. Our placental perfusion system appears promising for validating in vivo quantitative MRI.

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