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Abstract #0581

Placental MRI: Effect of maternal position, breath hold and oxygen state on placental T2* measurements

Esra Abaci Turk1, Jeffrey N. Stout1, Borjan Gagoski1, Mary Katherine Manhard2, Elfar Adalsteinsson3,4,5, Kawin Setsompop2, Polina Golland3,6, Drucilla J. Roberts7, William H. Barth Jr8, and P. Ellen Grant1
1Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 4Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 5Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 6Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States, 7Pathology, Massachusetts General Hospital, Boston, MA, United States, 8Maternal-Fetal Medicine, Massachusetts General Hospital, Boston, MA, United States

T2* relaxometry has been proposed as a semi-quantitative measure for placental oxygen transport. However, to use T2* as a diagnostic tool, it is necessary to define the normal range of results and factors that influence those results. In this study we investigated the effect of maternal position, breath-holds and oxygen state on placental T2*. We observed lower T2* with breath-hold protocol compared to no breath-hold protocol in left lateral position. Additionally, lower T2* was measured in supine position during normoxic episode compared to left lateral position with no breath-hold protocol. Further studies are needed to understand these factors better.

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