Abstract #0581

Placental MRI: Effect of maternal position, breath hold and oxygen state on placental T2* measurements

Esra Abaci Turk¹, Jeffrey N. Stout¹, Borjan Gagoski¹, Mary Katherine Manhard², Elfar Adalsteinsson^3,4,5, Kawin Setsompop², Polina Golland^3,6, Drucilla J. Roberts⁷, William H. Barth Jr⁸, and P. Ellen Grant¹

¹Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁵Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁶Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States, ⁷Pathology, Massachusetts General Hospital, Boston, MA, United States, ⁸Maternal-Fetal Medicine, Massachusetts General Hospital, Boston, MA, United States

T₂^* relaxometry has been proposed as a semi-quantitative measure for placental oxygen transport. However, to use T₂^* as a diagnostic tool, it is necessary to define the normal range of results and factors that influence those results. In this study we investigated the effect of maternal position, breath-holds and oxygen state on placental T₂^*. We observed lower T₂^* with breath-hold protocol compared to no breath-hold protocol in left lateral position. Additionally, lower T₂^* was measured in supine position during normoxic episode compared to left lateral position with no breath-hold protocol. Further studies are needed to understand these factors better.

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