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Abstract #0587

3D TSE Amide Proton Transfer and IVIM Imaging for Type I Endometrial Carcinoma: Correlation with Ki-67 Proliferation Status

Yong-Lan He1, Yuan Li1, Cheng-Yu Lin1, Ya-Fei Qi1, Xiaoqi Wang2, Hai-Long Zhou1, Hua-Dan Xue1, and Zheng-Yu Jin1
1Peking Union Medical College Hospital, Beijing, China, 2Philips Healthcare China, Beijing, China

This study demonstrates the first attempt of 3D TSE APTw MR imaging for endometrial carcinoma with excellent inter-observer measurement agreement. APT values on 22 type I endometrial carcinoma lesions were moderately positively correlated with Ki-67 labelling index (r = 0.583, p=0.004). APT values of Ki-67 low-proliferation group were significantly lower than high-proliferation group (p=0.016) with AUC 0.768. However, no correlation was found between IVIM-derived parameters and Ki-67 labeling index (Dt, p=0.717; D* p=0.151; f, p=0.153).

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